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GrainGenes Reference Report: SAD-8:eabn7258

Reference	SAD-8:eabn7258
Title	A lineage-specific Exo70 is required for receptor kinase-mediated immunity in barley
Journal	Science Advances
Year	2022
Volume	8
Author	[ Hide all but 1 of 23 ] Holden S Bergum M Green P Bettgenhaeuser J Hernández-Pinzon I Thind A Clare S Russell JM Hubbard A Taylor J Smoker M Gardiner M Civolani L Cosenza F Rosignoli S Strugala R Molnar I Simkova H Dolezel J Schaffrath U Barrett M Salvi S Moscou MJ
Abstract	In the evolution of land plants, the plant immune system has experienced expansion in immune receptor and signaling pathways. Lineage-specific expansions have been observed in diverse gene families that are potentially involved in immunity but lack causal association. Here, we show that Rps8-mediated resistance in barley to the pathogen Puccinia striiformis f. sp. tritici (wheat stripe rust) is conferred by a genetic module: Pur1 and Exo70FX12, which are together necessary and sufficient. Pur1 encodes a leucine-rich repeat receptor kinase and is the ortholog of rice Xa21, and Exo70FX12 belongs to the Poales-specific Exo70FX clade. The Exo70FX clade emerged after the divergence of the Bromeliaceae and Poaceae and comprises from 2 to 75 members in sequenced grasses. These results demonstrate the requirement of a lineage-specific Exo70FX12 in Pur1-mediated immunity and suggest that the Exo70FX clade may have evolved a specialized role in receptor kinase signaling.
External Databases	https://doi.org/10.1126/sciadv.abn7258
QTL	QRpsh_4H.2

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