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GrainGenes Reference Report: CJR-82-878

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Reference	CJR-82-878
Title	Fusaric acid, a Fusarium verticillioides metabolite, antagonistic to the endophytic biocontrol bacterium Bacillus mojavensis
Journal	Canadian Journal of Botany
Year	2004
Volume	82
Pages	878-885
Author	Bacon CW Hinton DM Porter JK Glenn AE Kuldau G
Abstract	An endophytic bacterium, Bacillus mojavensis , was patented as a nonpathogenic biological control agent for plant diseases. However, before this bacterium can be used as a biological control agent, it must be evaluated against homologous competing organisms, some of which are equally successful endophytes, such as species of Fusarium that are symptomless endophytes, especially on maize. Preliminary field trials using this bacterium as a biological control agent against production of the fumonisin mycotoxins caused by infection of maize (P3223) with F. verticillioides (= Fusarium moniliforme ) was less than that observed in greenhouse studies. F. verticillioides and other species produce fusaric acid. Fusaric acid at concentrations as low as 22 micromol/litre accounted for a 41% reduction in CFU compared with the control group, while concentrations of 223 micromol/litre and higher resulted in total toxicity to the bacterium. Mutants of F. verticillioides that produced low concentrations of fusaric acid did not affect the endophytic CFU of the bacterium in seedlings. Fusaric acid accounted for the reduction of bacterial colonization and the resulting poor biological control activity and suggested its importance to the fungus is as an antibiotic, which assists in the in planta competition for the intercellular niche colonized by F. verticillioides during its endotrophic state
Keyword	[ Hide all but 1 of 18 ] agricultural research biological control biological control agents colonization control endophyte fumonisins fungal diseases infection maize metabolites mutant mycotoxins plant diseases plant pathogenic fungi plant pathogens seedling toxicity

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