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GrainGenes Marker Report: Fr-A2 (Triticum)

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Gene	Fr-A2 (Triticum)
Gene Class	Frost resistance
Locus	Fr-A2 S2269949
Reference	Sieber AN et al. (2016) Copy number variation of CBF-A14 at the Fr-A2 locus determines frost tolerance in winter durum wheat Theoretical and Applied Genetics 129:1087-1097. Zhu J et al. (2014) Copy number and haplotype variation at the VRN-A1 and central FR-A2 loci are associated with frost tolerance in hexaploid wheat Theoretical and Applied Genetics 127:1183-1197. Miller AK et al. (2006) A cluster of 11 CBF transcription factors is located at the frost tolerance locus Fr-Am2 in Triticum monococcum. Molecular Genetics and Genomics 275:193. Francia E et al. (2004) Two loci on chromosome 5H determine low-temperature tolerance in a 'Nure' (winter) x 'Tremois' (spring) barley map Theoretical and Applied Genetics 108:670-680. Vagujfalvi A et al. (2003) The cold-regulated transcriptional activator Cbf3 is linked to the frost-tolerance locus Fr-A2 on wheat chromosome 5A. Molecular Genetics and Genomics 269:60-67.
URL	Fr-A2 gene at Komugi: Catalogue of Gene Symbols for Wheat
QTL Associated with Gene	QFSelt.wpg-5A.1
Germplasm	Diploid stock, T. monococcum ssp. aegilopoides G3116 Vagujfalvi A et al. (2003) The cold-regulated transcriptional activator Cbf3 is linked to the frost-tolerance locus Fr-A2 on wheat chromosome 5A. Molecular Genetics and Genomics 269:60-67. T. monococcum ssp. monococcum DV92 Vagujfalvi A et al. (2003) The cold-regulated transcriptional activator Cbf3 is linked to the frost-tolerance locus Fr-A2 on wheat chromosome 5A. Molecular Genetics and Genomics 269:60-67.
Comment	The QTL mapped on chromosome 5AL had a LOD score of 9 and explained 49% of the variation in frost tolerance (Vagujfalvi et al., 2003). The closest markers were Xbcd508-5A and Xucw90(Cbf3)-5A. These markers are 30 cM proximal to Xwg644-5A, which is closely linked to frost tolerance locus Fr-1. Eleven different Cbf transcription factors were identified at the Fr-A2 locus (Miller et al., 2006). QTLs for frost tolerance in the Fr-2 region were also identified in wheat chromosome 5B (Fr-B2) (Vagujfalvi et al., 2003) and in barley chromosome 5H (Fr-H2) (Francia et al., 2004).
Info Source	McIntosh RA et al. (2013) Catalogue of Gene Symbols for Wheat- 2013 Edition Catalogue of Gene Symbols for Wheat.
Data Curator	Cooper, Laurel Oct-2020
Locus Associated with Gene	Fr-A2
Type	Trait
Chromosome	5A
Chromosome Arm	5A
Map	Wheat-Composite2004-5A 36
	[ Show Nearby Loci ]
Species	Triticum aestivum
Probe	BCD508 S2269949
Associated Gene	Fr-A2 (Triticum)
Homology	T22388 e-value: 4.6 hypothetical protein F48F7.4 - Caenorhabditis elegans this gene~cDNA EST yk50c1.3 comes from this gene~cDNA EST yk50c1.5 comes from this gene~cDNA EST yk167b2.3 comes from this gene~cDNA EST yk167b2.5 comes from this gene~cDNA EST yk145e8.3>
Gene Class	Frost resistance
Reference	Vagujfalvi A et al. (2003) The cold-regulated transcriptional activator Cbf3 is linked to the frost-tolerance locus Fr-A2 on wheat chromosome 5A. Molecular Genetics and Genomics 269:60-67.
Remark	Trait marker Xbcd508-5A Nearby marker on Composite map: Xbcd508 Position on Composite map estimated by GrainGenes.
Locus Associated with Gene	S2269949
Chromosome	5A
Map	Wheat, Finch x Eltan 5A 116.8
	[ Show Nearby Loci ]
In QTL	QFSelt.wpg-5A.1
Map Data	Wheat, Finch x Eltan
Probe	S2269949
Associated Gene	Fr-A2 (Triticum)
Gene Class	Frost resistance

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