GrainGenes Reference Report: TAG-119-899
Reference
TAG-119-899
Title
Look before you leap: a new approach to mapping QTL.
Journal
Theoretical and Applied Genetics
Year
2009
Volume
119
Pages
899-911
Author
Huang BE George AW
Abstract
In this paper, we present an innovative and powerful approach for mapping quantitative trait loci (QTL) in experimental populations. This deviates from the traditional approach of (composite) interval mapping which uses a QTL profile to simultaneously determine the number and location of QTL. Instead, we look before we leap by employing separate detection and localization stages. In the detection stage, we use an iterative variable selection process coupled with permutation to identify the number and synteny of QTL. In the localization stage, we position the detected QTL through a series of one-dimensional interval mapping scans. Results from a detailed simulation study and real analysis of wheat data are presented. We achieve impressive increases in the power of QTL detection compared to composite interval mapping. We also accurately estimate the size and position of QTL. An R library, DLMap, implements the methods described here and is freely available from CRAN ( http://cran.r-project.org/ ).
External Databases
http://dx.doi.org/10.1007/s00122-009-1098-y
GrainGenes is a product of the Agricultural Research Service of the US Department of Agriculture.
GrainGenes Reference Report: TAG-119-899
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GrainGenes is a product of the Agricultural Research Service of the US Department of Agriculture. | |||