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GrainGenes Reference Report: NNB-4-389

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Reference	NNB-4-389
Title	The product of unr, the highly conserved gene upstream of N-ras, contains multiple repeats similar to the cold-shock domain (CSD), a putative DNA-binding motif
Journal	New Biology
Year	1992
Volume	4
Pages	389-395
Remark	Discusses transcription factor / regulator : CSD
Author	Doniger J Landsman D Gonda MA Wistow G
Abstract	We show that the open reading frame transcribed from the unr gene (immediately upstream of N-ras) in mammals consists of multiple repeats similar to the cold-shock domain (CSD), a putative DNA-binding motif found in prokaryotic cold-shock proteins, and eukaryotic DNA-binding proteins. Alignment of the CSD sequences of unr with those from other proteins reveals a core of similarity for which a consistent secondary structure prediction can be derived. This prediction suggests that the CSD consists primarily of beta-sheet, in contrast to most known eukaryotic DNA-binding proteins. Sequence analysis of the 3' end of the guinea pig unr gene shows that the core of one CSD repeat is encoded in a single exon, consistent with the modular assembly of the gene from ancestral CSD-coding units.
External Databases	https://www.ncbi.nlm.nih.gov/pubmed/1622933

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