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GrainGenes Reference Report: NRM-5-920

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Reference
NRM-5-920
Title
The LIM domain: from the cytoskeleton to the nucleus
Journal
Nature Reviews Molecular Cell Biology
Year
2004
Volume
5
Pages
920-931
Remark
Discusses transcription factor / regulator : LIM
Author
Kadrmas JL
Beckerle MC
Abstract
First described 15 years ago as a cysteine-rich sequence that was common to a small group of homeodomain transcription factors, the LIM domain is now recognized as a tandem zinc-finger structure that functions as a modular protein-binding interface. LIM domains are present in many proteins that have diverse cellular roles as regulators of gene expression, cytoarchitecture, cell adhesion, cell motility and signal transduction. An emerging theme is that LIM proteins might function as biosensors that mediate communication between the cytosolic and the nuclear compartments.
External Databases
https://www.ncbi.nlm.nih.gov/pubmed/15520811

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