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GrainGenes Reference Report: NCM-12:6915

Reference	NCM-12:6915
Title	The barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics
Journal	Nature Communications
Year	2021
Volume	12
Author	Bettgenhaeuser J [ Show all 17 ]
Abstract	Crop losses caused by plant pathogens are a primary threat to stable food production. Stripe rust (Puccinia striiformis) is a fungal pathogen of cereal crops that causes significant, persistent yield loss. Stripe rust exhibits host species specificity, with lineages that have adapted to infect wheat and barley. While wheat stripe rust and barley stripe rust are commonly restricted to their corresponding hosts, the genes underlying this host specificity remain unknown. Here, we show that three resistance genes, Rps6, Rps7, and Rps8, contribute to immunity in barley to wheat stripe rust. Rps7 cosegregates with barley powdery mildew resistance at the Mla locus. Using transgenic complementation of different Mla alleles, we confirm allele-specific recognition of wheat stripe rust by Mla. Our results show that major resistance genes contribute to the host species specificity of wheat stripe rust on barley and that a shared genetic architecture underlies resistance to the adapted pathogen barley powdery mildew and non-adapted pathogen wheat stripe rust.
External Databases	https://doi.org/10.1038/s41467-021-27288-3
QTL	QRpsh_1H.2

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