GrainGenes Reference Report: JFC-40-2279
Reference
JFC-40-2279
Title
Metabolism of sulfometuron-methyl in wheat and its possible role in wheat intolerance
Journal
Journal of Agricultural and Food Chemistry
Year
1992
Volume
40
Pages
2279-2283
Author
Anderson J Swain R
Abstract
[phenyl-(U)-(14)C]Sulfometuron-methyl was metabolized in excised wheat (sensitive to sulfometuron-methyl) to [(14)C]methyl 2-[[[[(4-(hydroxymethyl)-6-methylpyrimindin-2-yl)amino] carbonyl]amino]sulfonyl]benzoate (HM-SM) and its carbohydrate conjugate This metabolic pathway is consistent with sulfometuron-methyl metabolism in tolerant species such as Bermuda grass Sulfometuron-methyl was metabolized at a slower rate than metsulfuron-methyl in wheat When plants were exposed to [(14)C]methyl 4-hydroxy-2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)ami no]carbonyl]amino] sulfonyl]benzoate (HP-MM) and [(14)C]HM-SM the primary hydroxylated wheat metabolites of metsulfuron-methyl and sulfometuron-methyl, respectively), the rate of glucose conjugation of HP-MM was much faster than the rate of glucose conjugation of HM-SM Along with their parent compounds, both HM-SM and HP-MM are potent inhibitors of wild mustard acetolactate synthase These results indicate that wheat intolerance to sulfometuron-methyl but tolerance to the structurally closely related (metsulfuron-methyl) reflects not only a reduced ability to hydroxylate the parent molecule but also a reduced ability to conjugate the primary toxic metabolite to a nontoxic moiety.
Keyword
herbicide-resistance metabolic-detoxification metabolism sulfonylurea-herbicides triticum aestivum
GrainGenes is a product of the Agricultural Research Service of the US Department of Agriculture.
GrainGenes Reference Report: JFC-40-2279
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GrainGenes is a product of the Agricultural Research Service of the US Department of Agriculture. | |||