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GrainGenes Sequence Report: NC_011134_388.cds

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Sequence	NC_011134_388.cds
Structure From Source	NC_011134
Source Exons	1 570
Gene	grpE
Gene Product	heat shock protein GrpE
Remark	CDS note: similar to ref|NP_720560.1| heat shock protein GrpE (HSP-70 cofactor) [Streptococcus mutans UA159]; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with dnaK and grpE. It is the nucleotide exchange factor for dnaK and may function as a thermosensor. Unfolded proteins bind initially to dnaJ; upon interaction with the dnaJ-bound protein, dnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from dnaK; ATP binding to dnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- dependent interactions between dnaJ, dnaK and grpE are required for fully efficient folding. DB_xref: GI:195977544 DB_xref: GeneID:6760465 Feature: CDS: locus_tag = 'Sez_0401'; transl_table = 11; protein_id = 'YP_002122788.1';
Codon Start	1

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